Use of inflammatory markers of induced sputum for assessing the severity of late onset asthma and differential diagnosis
- VernacularTitle:诱导痰炎性标志物对老年人晚发哮喘严重程度判断和鉴别诊断的价值
- Author:
Hanxiang NIE
;
Changsheng LI
;
Jiong YANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Eosinophils;
Antimicrobial cationic protein;
Sputum
- From:
Chinese Journal of Geriatrics
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the eosinophil (Eos) percentage and levels of eosinophil cationic protein (ECP) in induced sputum and the severity of late onset asthma(LOA) and differential diagnosis. Methods Fifty-four patients with LOA were selected. The percentage of eosinophil and levels of ECP were measured by Wrigbt′s stain and immuno-CAP system respectively. The lung function was also evaluated. The same indexes were measured in 25 elderly patients with chronic obstructive pulmonary disease (COPD) and 10 healthy elderly subjects as control. Results The percentage of Eos and levels of ECP in induced sputum in patients with LOA were significantly and negatively correlated with FEV_1/FVC (r=-0.68,-0.61, respectively, P
