Effect of telmisartan on left ventricular hypertrophy in elderly patients with diabetes mellitus and essential hypertension
- VernacularTitle:替米沙坦对老年高血压伴糖尿病患者左室肥厚的治疗作用
- Author:
Xiaolin PENG
;
Zepeng LIN
;
Yousheng ZHAO
;
Ping HUANG
- Publication Type:Journal Article
- Keywords:
Telmisartan;
Hypertension;
Hypertrophy,left ventricular;
Peroxisomes;
Diabetes mellitus,non-insulin-dependent
- From:
Chinese Journal of Geriatrics
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of angiotensin Ⅱ antagonist on left ventricular hypertrophy(LVH) and insulin resistance in elderly patients with diabetes mellitus and hypertension. Methods One hundred and twenty elderly patients with diabetes mellitus and essential hypertension with LVH by echocardiography entered the study. Patients were randomized into the telmisartan (80～160 mg/d) group or perindopril (4～8 mg /d) group. After treatment of telmisartan or perindopril,patients were followed-up for 8 months.Plasma sample was collected from each patient before and after treatment of telmisartan or perindopril,respectively.Then plasma levels of cholesterol,fasting plasma glucose(FPG), insulin and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) were investigated.The echocardiography before and after 8 months of treatment with telmisartan or perindopril were also examined. Results Data were analyzed and showed that: (1)After 8 months of treatment with telmisartan or perindopril, blood pressure was reduced from 159/101 to 142/89 mm Hg(P
