Pharmacokinetics of tinidazole in saliva in healthy volunteers
- VernacularTitle:替硝唑口贴片在健康者唾液中药物浓度测定及其药代动力学
- Author:
Xiaojuan WANG
;
Chong DENG
;
Daoyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Tinidazole buccal patch;
RP-HPLC;
Pharmacokinetics
- From:
Journal of Practical Stomatology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the pharmacokinetic paramet er s of tinidazole in saliva. Methods:Tinidazole was separated on U ltrasphere ODS (C 18 column, 5 ?m,4.6 mm?25 cm)column with a mobile phas e of MeOH-2.33?10 -3 mol/L acetic acid 32∶68(v/v). The sample s were quantified with an ultraviolet detector operated at 310 nm. Resul ts:The saliva T max of the tinidazole tablets was (1.64?0.94) h,C max (69.23?11.39) ?g/ml,K e 0.059 6?0.013 2,T 1/2 (11.952?2.374) h,Auc (83.42?11.49) ?g?h/ml,Cl r 60.64? 8.56 and V r (2 704.45?601.42) ml respectively.Conclus ion:The method can be used for clinical monitoring of tinidazole in sali va.
