Neoadjuvant chrono-chemotherapy for the patients with oral squamous cell carcinoma
- VernacularTitle:口腔癌时辰化疗
- Author:
Kai YANG
;
Rui CHEN
;
Xiuli YU
- Publication Type:Journal Article
- Keywords:
Chrono-chemotherapy;
Neoadjuvant chemotherapy;
Car boplatin;
Fluorouracil;
Mouth;
Squamous cell neoplasms
- From:
Journal of Practical Stomatology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate therapeutic effect and toxici ti es of neoadjuvant chemotherapy(NACT) with Carboplatin(CBP) and 5-Fluorouracil (5-FU) for the patients with oral squamous cell carcinoma(OSCC)by chronomodul ated administration. Methods:73 patients with T3 and T4 OSCC, ad mitted from March 2002 to April 2004, were randomly divided into two groups,37 c ases were in chrono-chemotherapy group (groupⅠ) and 36 cases in routine-chemo therapy group (group Ⅱ). Therapeutic effects and side effects between tw o groups were compared.Results:After two NACT courses, the effec tive rate in group Ⅰ and group Ⅱ was 75.68% and 52.78%respectively (P
