Effect of Nimesulide on DMBA-Induced Mammary Tumors in Rats
- VernacularTitle:选择性COX-2抑制剂尼美舒利对大鼠乳腺癌的影响及机理研究
- Author:
Guilong GUO
;
Xiaohua ZHANG
;
Zhenxiang YAO
- Publication Type:Journal Article
- Keywords:
Nimesulide DMBA Mammary tumor Apoptosis
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of nimesulide (NIM) on DMBA-induced mammary tumors and to investigate possible mechanisms of inhibiting tumors. Methods The Wistar rats were randomly divided into four groups: DMBA group, NIM+DMBA group, NIM+diet group and diet group. The incidence and mean latent phase of mammary tumors were observed. The number and volume of tumors in every rat were measured. The apoptosis index and proliferation index were evaluated by TUNEL assay and PCNA immunohistochemical staining respectively.Results The latent phases of mammary tumors in NIM+DMBA group were strikingly longer than those in DBMA group 〔(115?14.8) d vs (84?15.6) d, P
