Quantitative electroencephalography effects of topiramate: a nonlinear analysis
- VernacularTitle:托吡酯药物定量脑电图研究的非线性分析
- Author:
Jianchuan LI
;
Weiwei WANG
;
Yinhua WANG
;
Xun WU
- Publication Type:Journal Article
- Keywords:
Fructose;
Electroencephalography;
Epilepsy;
Nonlinear dynamics
- From:
Chinese Journal of Neurology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of topiramate (TPM) on complexity of electroencephalography (EEG) by means of quantitative pharmacoelectroencephalography (QPEEG) and nonlinear analysis methods.MethodsOne dose of TPM was administrated to epileptics and healthy adults. The EEG samples were obtained prior to and at regular intervals (at 0.5, 1, 2, 4, 6, 8, 12, 24 hours after the administration) within 24 hours following the administration of TPM. The EEG activity was processed with the nonlinear analysis methods. The complexity measure, approximate entropy, Lyapunov exponent and fractional dimension of the whole scalp areas were calculated through 60 seconds epochs without artifacts after each recording. The statistical difference between baseline predrug assessment and each postdrug control was described by analysis of variance.ResultsThe Lyapunov exponent was increased first, then decreased, and then increased finally (the maximum value was 0.44 in both centrals in the healthy people). The approximate entropy and fractional dimension showed the tendency of descent, the complexity measure decreased in healthy adults (the least value was 0.34 on right parietal), but increased in patients (the maximum value was 0.34 in right posterior temporal).ConclusionTPM might change the complexity of EEG.
