Effect of gp120mAb on long-term potentiation inhibited by HIV-1 gp120 in rat hippocampus in vitro
- VernacularTitle:gp120mAb对gp120抑制大鼠海马脑片CA_1区LTP作用的研究
- Author:
Jun DONG
;
Zhenyou JIANG
- Publication Type:Journal Article
- Keywords:
HIV-1;
gp120mAb;
Long-term potentiation;
Hippocampal slices
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explor the effect of gp120mAb on synaptic transmission and plasticity changed by gp120 in the CA 1 region of rat hippocampal slices.Methods:We recorded the excitatory postsynaptic potentials (EPSP) and investigated effect of gp120mAb on long-term potentiation inhibited by gp120 in rat hippocampus in vitro.Results:The results showed that HIV-1 gp120 can inhibit the LTP induced by high-frequence stimulation schaffer in CA 1,gp120 had no effect on basal synaptic transmission.HIV-1 gp120(200 pmol/L) can inhibit the LTP maintance,gp120mAb of gp120-specific antibodies can reverse the inhibition effect,But IgG can't reverse it.Conclusion:The reverse effect of gp120-specific antibody gp120mAb on long-term potentiation inhibited by HIV-1 gp120 may contribute to the HAD pathogenesis.
