Effects of Formaldehyde on Protein Expressions of GluR2 and GABAR in Postnatal Rat Cortex Neurons in Culture
- VernacularTitle:甲醛对原代培养大鼠皮质神经元谷氨酸受体2和?-氨基丁酸受体蛋白表达的影响
- Author:
Ting LIU
;
Xuetao BAI
- Publication Type:Journal Article
- Keywords:
Formaldehyde;
Neuron;
Glutamate receptor2;
?-aminobutyric acid receptor
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To know the mechanism of the adverse effect of formaldehyde on cortex neurons. Methods In the present study, incubation of postnatal Wistar rat cortex neurons in culture with formaldehyde at 1.0, 2.0, 4.0, 8.0 mg/L (medium) was carried out to have knowledge of the effect of formaldehyde on the expressions of GluR2 and GABAR. For keeping the given concentration of formaldehyde, formaldehyde was added to the medium every hour for 4 consecutive hours. Results Immunocytochemistry showed a significant down-regulation of GluR2 and up-regulation of GABAR after 4 consecutive hours of formaldehyde treatment compared with the control (P
