Effects of Chronic Stress on the Expression of Bcl-xl in Hippocampus of the Rats
- VernacularTitle:慢性应激对大鼠海马Bcl-xl表达的影响及应激后的变化
- Author:
Bo BI
;
Zhe WANG
;
Miao PENG
- Publication Type:Journal Article
- Keywords:
Chronic stress;
Hippocampus;
Bcl-xl;
Forced-swimming
- From:Chinese Journal of Clinical Psychology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the changes of Bcl-xl expression in hippocampus of the rats with the forced-swimming and the changes of Bcl-xl after poststress. Methods: The protocol was established with the forced-swimming as the chronic stress model. Open-field test was executed to measure the behaviors of the rats. Immunohistochemistry was used to observe the changes of Bcl-xl expression in the hippocampus. Results: Compared to the control group,the expression of Bcl-xl in CA3 region of the hippocampus and dendate gyrus(DG)of the rats was decreased morphologically. With the computerized image analysis, the gray degree increased significantly (P
