Expression and clinical significance of E-cadherin gene protein in esophageal carcinoma
- VernacularTitle:表皮钙黏蛋白在食管癌组织中的表达及意义
- Author:
Jianhua FU
;
Dakuan YANG
;
Yunchao HUANG
;
Guoqian HU
- Publication Type:Journal Article
- Keywords:
esophageal carcinoma;
E-cadherin;
invasion and metastasis;
immunohistochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the expression of E-cadherin and the development, invasion and metastasis of esophageal carcinoma. Methods The expressions of E-cadherin in 58 cases with esophgeal carcinoma and 122 other cases with esophageal epithelial disease were examined by immunohistochemical technique. The relation between the expression of E-cadherin in esophageal carcinoma and the clinical pathological characteristics of esophageal carcinoma were analyzed. Results The expression rate of E-cadherin gene protein in esophageal squamous carcinoma and adenocarcinoma was 22.0%(11/50), 25.0%(2/8), respectively, compared with the normal group (100%, 20/20) and simple atypical hyperplastic group (92.9%, 26/28). The difference was significant (P
