The relationship between the expression of Cox-2 and iNOS and angiogenesis in gastric carcinoma
- VernacularTitle:Cox-2、iNOS的表达及其与胃癌血管生成的关系
- Author:
Hongxia LI
;
Zhengjun SONG
;
Shuixiang HE
;
Xinming CHANG
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
cyclooxygenase-2 (Cox-2);
inducible nitric oxide synthase (iNOS);
angiogenesis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the expression of cyclooxygenase-2(Cox-2) and inducible nitric oxide synthase (iNOS) and the angiogenesis in gastric carcinoma. Methods Immunohistochemical stain was used to detect the expression of Cox-2, iNOS and MVD in 45 resected specimens of gastric carcinoma. The monoclonal antibody against CD34 was used for displaying vascular endothelial cells, and MVD was detected by counting the CD34-positive vascular endothelia cells. Paracancerous tissues were examined as the control. Results The expression rates of Cox-2, iNOS and MVD in gastric cancer were significantly increased, compared with those in the paracancerous tissues (77.78% vs. 33.33%, 68.89% vs. 17.78%, 58.13?19.99 vs. 24.02?10.28, P
