Evaluation of the security and biocompatibility of bioabsorbable composites PDLLA-CPP
- VernacularTitle:PDLLA-CPP复合材料的安全性和生物相容性评价
- Author:
Jinshan XUE
;
Dong FANG
;
Wen ZHANG
;
Ailing YANG
;
Qinghu ZHANG
- Publication Type:Journal Article
- Keywords:
calcium polyphosphate fibers;
absorbable biomaterial;
biocompatibility;
cartilage cell
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the security and biocompatibility of a new kind of absorbable high-strength PDLLA-CPP composite, which is used for internal fracture fixation. Methods According to the national standard of the procedure of appraise in food security and toxicology, micronucleus test of bone marrow cell, spermatic aberration test, chromosomal aberration test, and teratogenic test were measured with IP maximal tolerance dose of maceration extract from PDLLA-CPP composites. Meanwhile, chondrocyte culture with PDLLA-CPP composite was used to evaluate the effect of PDLLA-CPP composite on cartilage cell proliferation. Results Micronucleus test of bone marrow cell, spermatic aberration test, chromosomal aberration test, and teratogenic test were not affected by IP maximal tolerance dose of PDLLA-CPP maceration extract. PDLLA-CPP composite also had no cytotoxicity on cartilage cell proliferation. Conclusion PDLLA-CPP is a new and safe medical material with good biocompatibility and absorbability.
