Study of correlation of pathology factors and prognosis of gastrointestinal stroma tumor

VernacularTitle:胃肠道间质瘤病理学因素与预后的相关性研究
Author: Wenqi BAI ; Zhetao MI ; Xiaobo LIANG ; Hongying LI ; Yanfeng XI
Publication Type:Journal Article
Keywords: Gastrointestinal stromal tumors; Pathology; CD117; Ki-67; Prognosis
From: Cancer Research and Clinic 2009;21(5):341-342,345
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation of pathology factors and prognosis of gastrointestinal stroma tumors (GIST). Methods The expression of CD117, CD34, SMA, S-100 and Ki-67 in 91 GIST cases were studied by Envision method of immunohistocbemistory;Sequently, the relationship of the location, the size, the hemorrhage, cellular necrosis, stroma mucus, the mitosis, Ki-67 expression and the prognosis were analyzed by SPSS 12.0. Results The positive rate of CD117, CD34, SMA, S-100 were 80.21%, 73.63 %, 34.07 %, 7.69 % respectively. There had significant difference between the location, the mitosis, Ki-67 expression and the prognosis; but no significant difference between the location, the hemorrhage, cellular necrosis, stroma mucus, CD117 expression and the prognosis. Conclusion The tumor's size, mitosis, and Ki-67 expression are associated with prognosis; CD117 expression and prognosis. Even more, Ki-67 expression may be a more precise factor to judge the tumor's biological behaviour compared to the mitosis. As a wally classified method, the Flecther classification is worth to spread.