Expression of CXCR4 in lung cancer and its significance
- VernacularTitle:CXCR4在肺癌组织中的表达及临床意义
- Author:
Liping SU
;
Jinping ZHANG
;
Jin CHEN
- Publication Type:Journal Article
- Keywords:
lung cancer;
CXCR4;
expression
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the expression and significance of CXCR4 in human lung cancer. Methods:Real-time RT-PCR and immunohistochemistry were performed to detect the expression of CXCR4 on 36 lung cancer specimens and 10 normal lung specimens taken from non-cancerous regions adjacent to lung cancer tissue. Results:34 of 36 cases showed positive staining of CXCR4 protein compared with normal lung specimens.CXCR4 expression was independent of pathological type or histological grade. However, in all examined cases, higher expression of CXCR4 tended to be detected in the tumor specimens with lymph node metastasis or regional invasion. Conclusions:Up-regulated expression of CXCR4 was detected in the early stage of lung cancer, and high-level expression of CXCR4 was associated with lung cancer having metastasis.
