Relationship between the expression of cyclin B1 gene and drug resistance in patients with acute leukemia
- VernacularTitle:急性白血病患者细胞周期蛋白B1基因表达与耐药的关系
- Author:
Huijun MU
;
Ping XIE
- Publication Type:Journal Article
- Keywords:
Cyclin B1;
Acute leukemia;
RT-PCR
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the relation between the expression of cyclinB1 gene and drug resistance in patient with acute leukemia. Methods:Cyclin B1 gene mRNA expression in 13 cases of drug resistant and 14 drug non-resistant acute leukemia patients’ peripheral blood have been determinated by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR).The expression of mdr1 gene mRNA in these patients was measured with fluorescence -quantitative reverse transcription-polymerase chain reaction (RT-PCR). Results:The expression of cyclin B1 mRNA in the drug resistant group was significantly higher than the drug non-resistant group cyclin B1 mRNA (P
