Reversal effects of carvedilol on multidrug resistance in bladder cell lines
- VernacularTitle:卡维地洛逆转膀胱癌细胞株多药耐药性
- Author:
Yuanning ZHANG
;
Tangjun YANG
;
Xiangwei WANG
- Publication Type:Journal Article
- Keywords:
bladder cancer;
carvedilol;
multidrug resistance
- From:China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the reversal effects on multidrug resistance in multidrug-resistent bladder cell lines BIU-87/ADM. Methods:The degree of drug-resistence was detected by MTTmethod; the concentration of ADM in cells BIU-87 and BIU-87/ADM was detected after the cells were treated by carvedilol and ADM. Results:Pretreatment by carvedilol increased the concentration of ADM in BIU-87/ADM cells, ,and the concentration was much higher than that in those cells treated by ADM only. Conclusions:Carvedilol can enhance the cytotoxic effect of ADM,and can reverse the multidrug resistance in bladder cancer lines BIU-87/ADM.
