Effects of stem cell factor in combination with erythropoietin on erythropoiesis in patients with anemia associated with non-Hodgkin's lymphoma
- VernacularTitle:干细胞因子与促红细胞生成素联合应用对非霍奇金淋巴瘤贫血患者红系生成的作用
- Author:
Junxia GU
;
Yan CHEN
;
Chun ZHANG
- Publication Type:Journal Article
- Keywords:
non-Hodgkin’lymphoma;
anemia;
stem cell factor;
erythropoietin
- From:China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To explore the effects of stem cell factor(SCF) in combination with erythropoietin (EPO) on erythropoiesis in patients with anemia associated with non-Hodgkin's lymphoma (NHL). Methods:Bone marrow (BM) mononuclear cells (MNC) from NHL patients and normal simples were cultured for 7 consecutives days in the presence or absence of SCF, EPO, and SCF+EPO in liquid medium. Erythropoiesis was analyzed by calculating the fraction of recovered erythroid cells and by flow cytometry. Results:Cultures stimulated with SCF+EPO contained a marked increased fractions of recovered erythroid cells compared to cells cultured in EPO alone in NHL simples (P
