Advances in the research on Tiam 1 and tumor invasion and metastasis
- VernacularTitle:T淋巴瘤侵袭转移诱导因子1与肿瘤侵袭转移的研究进展
- Author:
Jinming ZHU
;
Peiwu YU
- Publication Type:Journal Article
- Keywords:
tumor;
invasion;
metastasis;
Tiam 1
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
As a guanine nucleotide dissociation stimulator (GDS) of Rho-like GTPases, T lymphoma invasion and metastasis inducing factor 1(Tiam 1)possesses such biological functions as regulating reconstruction of cytoskeletal structure and migratory potential of cells. Studies had shown that over-expression of Tiam 1 was able to induce invasion and metastasis of tumor cells, the molecular biological basis of which includes the interactions between Tiam 1 and trans-membrane system of cytoskeleton, adhesion molecules and extra-cellular matrix, the effect on proliferation and apoptosis of tumor cells exposed by Tiam 1, as well as the activities of Tiam 1 regulated by other invasion and meatstasis associated factors. Simultaneously, these experimental results suggested that much more work would be needed in Tiam 1 on the diversity of its activity regulation ,the specificity of its biological effect, the realationship among Tiam 1 with other invasion and metastasis associated factors, as well as their mechanisms of signal transduction.
