The reversal effect of tamoxifen on the expression of MDR1 in pancreatic cancer
- VernacularTitle:三苯氧胺对人胰腺癌细胞mdr1基因表达逆转作用的实验研究
- Author:
Sheng LI
;
Chunying WANG
;
Bo ZHANG
;
Lei ZHAO
;
Wensheng YU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms?TAM?Gene,mdr1
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the reversal effect of tamoxifen(TAM)on the expression of mdr1 in human pancreatic cancer cell lines.Methods:The inhibtion effect of TAM on pancreatic cancer cell line SW1999、Capan-Ⅱ and mammary cancer cell line T47D were studied;The influence of TAM on mdr1 protein/mRNA expression in SW1999、Capan-Ⅱ and T47D were studied using the method of flow cytometer and RT-PCR.Results:The high dose TAM could inhibit Capan-Ⅱ cell line.TAM could reverse the expression of mdr1 protein and mRNA in Capan-Ⅱ cell line and T47D cell line. Conclusion:The high dose TAM could inhibit Capan-Ⅱ cell line,maybe related with reduction of the expression of mdr1 protein and mRNA.
