Gene expression profile in thymic carcinoid tumors with ectopic ACTH syndrome by gene chip technique
- VernacularTitle:以基因芯片技术研究胸腺类癌引起异位ACTH综合征的基因表达
- Author:
Yufang BI
;
Lei YE
;
Guang NING
;
Ling JIANG
;
Huiyong FAN
;
Chunjun ZHAO
;
Ji ZHANG
;
Kankan WANG
;
Meng DAI
;
Shouyue SUN
;
Yongju ZHAO
;
Zhongyuan CHEN
;
Xiaolong JIN
;
Xiaoying LI
;
Weiqing WANG
- Publication Type:Journal Article
- Keywords:
ACTH syndrome, ectopic;
Carcinoid tumor;
Thymus neophasms;
Oligonucleotide array sequence analysis;
Gene expression profiling
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the differential gene expression between thymic carcinoids and normal thymic tissues and to study thepathogenesisofectopicACTH syndrome caused by thymic carcinoids. Methods Using gene chip technique, the gene differential expression of 2 tissues were observed following RNA labeled with different fluorescences (Cy3 and Cy5) hybridized to gene chip. Results Among 4224 genes on gene chip, 394 were up regulated more than 2 folds in thymic carcinoid tissues, 23 of which were associated with cell mitosis; 51 genes were upregulated more than 5 folds, 1 of which (PAK3) was associated with cell mitosis. Conclusion A group of differentially expressed genes were observed between the thymic carcinoids and normal thymic tissues.These overexpressed and cell mitosis-associated genes probably play a role in the pathogenesis of thymic carcinoid tumors.
