Comparison of the effects of glimepiride and glibenclamide on neuropeptide Y secretion from hypothalamus in diabetic KK-Ay mice
- VernacularTitle:格列美脲与格列本脲影响KK-Ay小鼠下丘脑神经肽Y分泌的比较研究
- Author:
Xiaoman ZOU
;
Fangling MA
;
Juming LU
;
Changyu PAN
- Publication Type:Journal Article
- Keywords:
Glimepiride;
Glibenclamide;
Neuropeptide Y;
Leptin;
K_ ATP channel;
Body fat
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic KK-Ay mice were given glimepiride (GM) and glibenclamide (GB). After treatment, the visceral white fat content, insulin and hypothalamic neuropeptide Y (NPY) levels were significantly lower in GM group than those in GB group, suggesting that in addition to the lower insulin level stimulated by GM, the lower concentration of hypothalamic NPY seems to play a role in lessening increase in body fat of type 2 diabetic animals treated with GM.
