The expression of hyaluronidase and VEGF on human breast cancer invasion and metastasis
- VernacularTitle:透明质酸酶与血管内皮生长因子在人乳腺癌侵袭与转移中的作用
- Author:
Yi WANG
;
Guosheng REN
;
Yuan SHI
;
Xiaoyi WANG
- Publication Type:Journal Article
- Keywords:
Hyaluronidase;
Matrix Metaloproteinase- 9;
Breast cancer;
Metastasis
- From:
Cancer Research and Clinic
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hyaluronidase and VEGF on human breast cancer invasion and metastasis. Methods By means of ELSA and immunohistochemistry, hyaluronidase and VEGF were detected in breast cancer. Results Hyaluronidase were (3.99?1.91) mU/g, (8.01?2.59) mU/g and (12.00?3.96) mU/g in gradeⅠ, Ⅱ, Ⅲ of breast cancer respectively. Hyaluronidase levels were significantly elevated in grade Ⅱ,Ⅲ as compared to grade Ⅰ, Hyaluronidase levels were significantly elevated in grade Ⅲ as compared to grade Ⅱ(P
