Pharmacological study of apoptosis on antileukemia effect of Carboxymethyl pachymaran
- VernacularTitle:羧甲基茯苓多糖抗小鼠白血病凋亡药理学研究
- Author:
Yong YANG
;
Hongxin YANG
;
Xiaohong YAN
- Publication Type:Journal Article
- Keywords:
Carboxymethyl pachymaran;
Leukemia;
bcl- 2;
Apoptosis
- From:
Cancer Research and Clinic
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antileukemia effect of Carboxymethyl pachymaran (CMP) on p388 leukemia mice and its molecular mechanism. Methods After establishing leukemia normal model, they were randomly divided into groups and treated at the same time. FCM and mRNA in situ hybridization(ISH) and S- P assay immunocytochemistry were used for apoptosis and the expression of bcl- 2 mRNA and bcl- 2 protein in peripheral blood lymphocyte samples. Results CMP could prolong the span time of tumor- bearing mice 35.88 %, it was significant for CMP group compared with model group( P
