A study on pathway of apoptosis in murine thymocytesinduced by candida albicans
- VernacularTitle:白色念珠菌诱导小鼠胸腺细胞凋亡通路的探究
- Author:
Ming JI
;
Chaofan WEI
;
Yuxiao CHEN
;
Hongmin JIANG
- Publication Type:Journal Article
- Keywords:
Candida albicans;
Thymocyte;
Apoptosis;
TNF-?;
caspase-3;
Bax;
p53
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the pathway of C.albicans-induced murine thymocyte apoptosis.Methods:The chages of TNF-? level in murine plasma and caspase-3 activity were measured by ELISA and flurorescence spectrophoto meter respectively;FCM measurement was adopted for the expression levels of related genes.Results:The level of TNF rise,the caspase-3 activity serengthen significantly and bax,p53 gene expression are upregulated.Conclusion:It is possible that C.albicans elicits apoptosis in murine thymocytes by upregulating bax and p53 gene expression as well as raising the serum TNF-? level to strenghen the activity of caspase-3.
