Small Hepatocellular Carcinoma:Multivariate Regression Analysis of Correlation of Pseudocapsula Completion on Multiphase Spiral CT with Histopathological and Immunohistochemical Findings
- VernacularTitle:小肝癌SCT包膜完整性与组织病理及免疫组化的多因素相关性研究
- Author:
Bingfeng LU
;
Zhongkui HUANG
;
Liling LONG
- Publication Type:Journal Article
- Keywords:
small hepatocellular carcinoma;
tomography, X-ray computed;
pathology;
gene;
VEGF;
antigens
- From:
Journal of Practical Radiology
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship among SCT features of tumor margin and tumor size, immunohistochemical findings, grade of cell differentiation, and to explore the potency of tumor marginal features on multiphase spiral CT for evaluating biological behavior of small hepatocellular carcinoma (SHCC).Methods Multiphase spiral CT scans were performed in 30 patients with 33 lesions of SHCC (≤3.0 cm in diameter) confirmed histopathologically. Of these patients,26 were male and 4 were female. Immunohistochemical and HE staining were performed in surgical samples of all patients with SHCC. All samples' size was measured and the number of masses in each patient was counted.Results Of all masses, 6 were complete capsule, 15 incomplete capsule and 12 non-capsule. In multiple linear regression analysis, the pseudocapsula presentation and completion of SHCC on SCT were positively related with tumor size and VEGF expression, negatively with CD34 and p21, and were not in association with p53 and histological grade. Tumor size was the strongest contributor to pseudocapsula completion(R=0.5115), and then VEGF(R=0.2917), CD34(R=-0.2981) and p21(R=-0.2726), which had the similar standardized regression coefficients.Conclusion Tumor size is the strongest relative factor that influenced pseudocapsula presentation and completion of SHCC. VEGF always expressed positively in SHCC with complete pseudocapsula, and negatively in the group of SHCC with incomplete pseudocapsula or without pseudocapsula. In the group of SHCC with incomplete pseudocapsula or without pseudocapsula, p21 always express positively. Neither p53 expression nor histological grade is in association with the pseudocapsula presentation and completion of SHCC on SCT.
