Effect of gadolinium chloride on suppressing acute rejection following liver allograft transplantation in the rats
- VernacularTitle:氯化钆抑制大鼠肝移植急性排斥反应的机理
- Author:
Yong PENG
;
Jianping GONG
;
Changan LIU
- Publication Type:Journal Article
- Keywords:
Chlorides;
Kupffer cells;
Liver transplantation;
Rats
- From:
Chinese Journal of Organ Transplantation
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of gadolinium chloride (GdCl3) inhibiting Kupffer cells (KCs) to suppress acute rejection following liver allograft transplantation in the rats. Methods The rats were randomly divided into control group (A), liver transplantation with GdCl3 pretreatment group (B), and liver transplantation with normal saline pretreatment group (C). The survival rate, liver function, hepatic pathological histology, cytokine level in liver and bile, activity of NF-?B in KCs, and membraneous molecules on the KCs were observed. Results (1) The one-month survival rate in group B was significantly higher than that in group C (P
