The effects of irbesartan on the endothelial dysfunction in the elderly with essential hypertension
- VernacularTitle:伊贝沙坦对老年原发性高血压患者血管内皮功能的影响
- Author:
Xiangting TIAN
;
Ping HUANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Nitric oxide;
Endothelium, vascular;
Angiotersin-converting enzyme inhibitors
- From:
Chinese Journal of Geriatrics
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate (1) whether or not irbesartan can relieve endothelial dysfunction of essential hypertension; (2) which of fosinopril and irbesartan is better in relieving the endothelial dysfunction in essential hypertension, especially for the elderly . Methods Sixty-two elderly patients with essential hypertension were divided into two groups: fosinopril group and irbesartan group. After 3 months treatment, the effect of drugs on BP and the endothelium-dependent relaxation(EDR) of brachial artery (BA) with high resolution ultrasound examination were analyzed, meanwhile the plasma levels of NO、ET-1 and vWF were assessed. Results Fosinopril and irbesartan groups had a similar (P
