Carotid atherscleross and angiotensin Ⅱ type 1 receptor gene polymorphism in primary hypertension
- VernacularTitle:原发性高血压患者颈动脉粥样硬化与AT_1R基因多态性的关系
- Author:
Shiming ZHU
;
Shuang LIU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Gene experssion profiling;
Angiotensin Ⅱ
- From:
Chinese Journal of Geriatrics
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between angiotensin Ⅱ type 1 receptor (AT_~1 R) gene polymorphism and carotid atherosclerosis and pathogenesis in primary hypertension . Methods Polymerase chain reaction combined with restriction enzyme digestion and ultrasonography were used to measure AT_~1 R gene polymorphism and carotid artery intima-media thickness (IMT) separately in 150 patients with primary hypertension compared with 100 controls . Results The frequencies of AC genotype and C allele of AT_~1 R gene in patients were higher than those of control ~(P
