Expression of Livin protein and its relationship with Caspase-3, FHIT protion in skin squamous cell carcinoma
10.3760/cma.j.issn.1006-9801.2009.05.008
- VernacularTitle:Livin在皮肤鳞状细胞癌中的表达及其与FHIT、Caspase-3相关性的初步研究
- Author:
Jun XING
;
Baolin ZHANG
- Publication Type:Journal Article
- Keywords:
Skin neoplasms;
Neoplasms,squamous cell;
Caspase-3;
Fragile histidine triad;
lmmunohistochemistry;
Livin
- From:
Cancer Research and Clinic
2009;21(5):311-313,316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Livin and its relationship with Caspase-3, FHIT in skin squamous cell carcinoma. Methods lmmunohistochemical assay was used to detect the expression of Livin, Caspase-3 and FHIT in 48 cases of sSCC, 20 cases of chronic ulcer and 12 cases of normal skin tissues. Results The rate of positive expression of Livin in SCC tissues was significantly higher than that in the chronic ulcer tissues and normal skin tissues (P <0.01). The rate of positive expression of Caspase-3 and FHIT in SCC tissues was significantly lower than that in the chronic ulcer tissues and normal skin tissues (P < 0.01).The expression of Livin and Caspase-3 had relationship with the lymphatic metastasis and histologic differentiation of SCC(P <0.05). The expression of Livin and Caspase-3 had not relationship with age, sex, the sizes of SCC (P >0.05). There was negative significant correlation between the expression of Livin and the expression of Caspase-3, FHIT. Conclusion There may be relationship between the abnormal expression of Livin and Caspase-3, FHIT and the occurrence, progression of skin squamous cell carcinomas. They may become a new method for preservation and treatment skin of squamous cell carcinomas.
