Intravenous immunoglobulin therapy in the pulmonary infection after renal transplantation
- VernacularTitle:免疫球蛋白在肾移植后肺部感染治疗中的辅助作用
- Author:
Guobing WENG
;
Li TANG
;
Jiguang JIANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Lung;
Infection;
Combined modality therapy;
Immuno-globulins
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the adjunctive therapeutic effect of intravenous immunoglobulin (IVIG) therapy in the pulmonary infection after kidney transplantation.Methods In 14 cases of pulmonary infection after kidney transplantation, 8 and 6 cases were subjected to high dose (7 to 10 days, group A) or low dose (3 to 7 days, group B) of IVIG therapy besides the standard specific anti-pathogen therapy. In 12 cases of pulmonary infection after kidney transplantation, only standard specific anti-pathogen therapy was given (group C). The incidence and mortality of severe pulmonary infection, levels of serum IgG, IgA, IgM and T lymphocyte subsets among the three groups were observed.Results The incidence of severe pulmonary infection was 0, 66.7 % and 66.7 % respectively in groups A, B and C with the mortality being 0, 16.7 % and 25.0 % respectively. The level of serum IgG was significantly increased in group A after treatment as compared with that before treatment and in group B ( P 0.05 ).Conclusion As an adjunctive therapy, high dose of IVIG at early stage of pulmonary infection can reduce the incidence of severe pulmonary infection and mortality after kidney transplantation.
