Expression and significance of MCP-1 and RANTES in renal tissue of chronic allograft nephropathy
- VernacularTitle:单核细胞趋化因子-1和RANTES在慢性移植肾肾病大鼠肾组织中的表达及意义
- Author:
Guoqin WANG
;
Hequn ZOU
;
Juan YAO
- Publication Type:Journal Article
- Keywords:
Transplants;
Kidney diseases;
Kidney Transplantation;
Chemokines
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of monocyte chemoattractant protein 1 (MCP-1) and RANTES and their significance in the pathogenesis of chronic allograft nephropathy.Methods Uninephrectomized F344 rats and LEW rats were used as control animals. Left renal transplantation LEW rats were used as experimental animals. Twelve weeks after transplantation, the renal function and the histological disorders of chronic allograft nephropathy were studied. The expression of MCP-1 and RANTES in the allografts was detected by immunohistochemistry.Results Compared with F344 control groups, the serum creatitine level ( 96.200 ? 36.405 ) ?mol/L in the experimental groups was increased ( P
