Effect of Yisheng herbal injection on chronic allograft nephropathy in rat
- VernacularTitle:益生注射液延缓大鼠慢性移植肾肾病的进程
- Author:
Yupeng XIN
;
Yiping LU
;
Rui GAO
- Publication Type:Journal Article
- Keywords:
Composite(TCD);
Rats;
Kidney transplantation;
Transplants;
Kidney failure, Chronic
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive and therapeutic effectiveness of Yisheng herbal injection against chronic allograft nephropathy in rats.Methods Renal transplantation was performed from SD to Wistar closed colony strain rats. Before the transplantation, the kidney was preserved in 0- 40 ℃ heparin sodium chloride solution for one h. The rats were divided into 4 groups: Group A only received CsA 10 mg/kg every day; Groups B, C and D received low dose of Yisheng+CsA, high dose of Yisheng+CsA and CsA+MMF, respectively. Blood creatinine, pathological changes of the renal grafts and the expression of transforming growth factor ?1 in transplanted renal tissues were observed 4, 8 and 12 weeks after operation.Results After the transplantation, the serum creatinine level in group A was significantly higher than in groups B, C and D ( P
