The Effect of Bisphenol A and Dibutyphthlate Treated With Rat Liver S9 on Proliferation of MCF-7 Cells
- VernacularTitle:双酚A和邻苯二甲酸二丁酯对人乳腺癌细胞株MCF-7细胞增殖的影响
- Author:
Lijuan ZHANG
;
Jun LI
;
Xueyun FAN
- Publication Type:Journal Article
- Keywords:
MCF-7 cells;
Liver S9;
17?-estradiol;
Bisphenol A;
Dibutyphthlate;
Cell proliferation
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of bisphenol A (BPA) and dibutyphthlate (DBP) treated with Rat Liver S9 on proliferation MCF-7 cells. Methods Added the positive control 17?-estradiol (E2) and compounds of BPA and DBP with the effect of Rat Liver S9 to MCF-7 cells proliferation respectively and determinated the quantity of MCF-7 cells with MTT assay. Results The activity of E2 and DBP stimulated MCF-7 cells decreasing significantly with the effect of Liver S9 than without the effect of Liver S9, while BPA stimulated MCF-7 cells increasing significantly with the effect of Liver S9 than that without the effect of Liver S9. Conclusion E2 and DBP have a lower estrogenic activity with the effect of S9 than without the effect of S9. BPA shows a higher estrogenic activity with the effect of S9 than without the effect of S9.
