Experimental Study on Lung Cancer Induced by Cooking Oil Fumes in SD Rats
- VernacularTitle:烹调油烟诱发大鼠肺癌的实验研究
- Author:
Liliang LONG
;
Feng CHEN
;
Xingpeng HE
- Publication Type:Journal Article
- Keywords:
Lung neoplasma;
Cooking oil fumes;
p53 protein;
FHIT protein
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). The pulmonary carcinoma incidence rate of the rats treated at the dosages of (6.88?0.31) mg/m3, (15.06?0.35) mg/m3 and (35.33?1.69) mg/m3 were 6.56%?8.96% and 12.70% respectively. Immunohistochemical staining showed that COF could induce abnormal expression of p53 and FHIT protein in lung tissue. Only in experimental group the positive expression of mutant p53 protein located in bronchi epithelial cell nucleus were found. The positive expression rate of p53 protein in lung tissue section of tumor cases was significantly higher than that of control group(P
