Clinical experimental research on the treatment of chronic hepatitis-B with the combination of jiudaiqingyuan oral solution and lamivudine
- VernacularTitle:九代清源口服液联合拉米夫定治疗慢性乙型肝炎的临床实验研究
- Author:
Lin LI
;
Qiushi LI
- Publication Type:Journal Article
- Keywords:
Jiudaiqingyuan oral solution;
Lamivudine;
Chronic Hepatitis-B
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of jiudaiqingyuan oral solution in the treatment of chronic hepatitis-B(CHB) and in the elimination of HBV when used alone and combined with lamivudine.Methods:108 CHB patients were randomly divided into three groups:treatment group with Jiudaiqingyuan Oral Solution (Jiudai group),Lamivudine treatment group (lamivudine group),and treatment group with the combination of Jiudaiqingyuan Oral Solution and lamivudine (combination group),with each group including 36 cases.Laboratory tests were done before treatment,3,6,9 and 12 months after treatment,and at the 3rd,6th and 12th month of follow-up.The laboratory tests consisted of ALT,HBV-M and HBV-DNA.Results:At the 12th month of treatment and 12th month of follow-up,cases with normal ALT conversion cases with negative HBV-DNA conversion,cases with negative HBeAg conversion,HBeAg/anti-HBe serum conversion rate,and total effective rate of the combination group were respectively 94.4%,86.1%,55.6%,52.8%,75.0% and 83.3%,72.2%,47.2%,47.2%,72.2%,which were markedly better than those of Jiudai group or lamivudine group,with significant statistc difference in each index (P
