Nasal Rhinoscleroma in a Nonendemic Area: A Case Report.
10.3346/jkms.2003.18.3.455
- Author:
Na Rae KIM
1
;
Joungho HAN
;
Tae Young KWON
Author Information
1. Department of Pathology, Kangnam General Hospital Public Corporation, Korea.
- Publication Type:Case Report
- Keywords:
Rhinoscleroma;
Klebsiella Rhinoscleromatis;
Macrophages;
Microscopy, Electron
- MeSH:
Endemic Diseases;
Fibrosis;
Human;
Klebsiella pneumoniae/*isolation & purification;
Korea;
Male;
Microscopy, Electron;
Middle Aged;
Nasal Mucosa/*microbiology/pathology/ultrastructure;
Rhinoscleroma/*pathology
- From:Journal of Korean Medical Science
2003;18(3):455-458
- CountryRepublic of Korea
- Language:English
-
Abstract:
Rhinoscleroma is a chronic, granulomatous infectious lesion most frequently affecting the respiratory tract mucosa. This disease is endemic to Africa, Central and South America, South Central and Eastern Europe, the Middle East, and China. We report an extremely rare disease of nasal rhinoscleroma in Korea. The patient was a 63-yr-old man, who suffered from chronic nasal obstruction and septal deviation. Characteristic histology from a nasal biopsy was proven and special stains for bacteria were employed: periodic acid-Schiff, Warthin-Starry silver, Giemsa, and Gram stains. Isolation of Klebsiella rhinoscleromatis from a culture of nasal discharge was failed, but ultrastructural examination of numerous phagocyzed bacilli in the Mikulicz cells confirmed the diagnosis. The histiocytic nature of the Mikulicz cells was confirmed, using CD 68 and alpha-1 antitrypsin, and by the ultrastructural features of Mikulicz cells. Here, we emphasize the recognition of this rare entity in nonendemic regions, frequently leading to delayed diagnosis.
