Expression and clinical studies on FLK-1,LRP and MDR1 in lung cancer patients
- VernacularTitle:肺癌患者FLK-1、LRP和MDR1的表达与临床研究
- Author:
Chunrong ZHU
;
Xueming XIA
;
Qingcai WANG
- Publication Type:Journal Article
- Keywords:
Flk-1 gene;
MDR1 gene;
LRP gene;
gene expr ession;
immunohistochemistry;
lung cancer;
prognosis
- From:China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the effect of Flk-1、LR P and MDR1 genes in the carcinogenesis and development of lung cancer. Methods:The expression of Flk-1、LRP and MDR1 geneproteins in primary lung tumors were studied immunohistochemically. Results:of the 70 lung cancers, 29 cases (49.2%) were positive for MDR1 expression in NSCLCs and 2cases (18.2%) in small cell lung carcinoma(S CLC); 41cases (69.5%)had overexpression of LRP in NSCLCs and 3cases (27.3%) in S CLCs, there was a statistically significant correlation (P
