Mechanism of inhibitory effects of atropine and anisodamine on contractions of rabbit thoracic aorta
- VernacularTitle:阿托品和山莨菪碱抑制兔胸主动脉收缩的作用机制
- Author:
Shuqin LIU
;
Weijin ZANG
;
Zengli LI
;
Qiang SUN
;
Xiaojiang YU
- Publication Type:Journal Article
- Keywords:
atropine;
anisodamine;
rabbit aorta;
noradrenaline;
histamine;
5-hydroxytryptamine
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05, respectively), but those to noradrenaline (NA: 0.01?mol/L), histamine (His: 3?mol/L), and 5-hydroxytryptamine (5-HT: 0.1?mol/L), significantly reduced (P0.05, respectively). Under atropine or Ani pretreatment, the NA-, His- and 5-HT-elicited contractions in endothelium-denuded aorta were similar to those in endothelium-intact aorta. Conclusion Atropine and Ani can inhibit receptors-mediated constrictions of rabbit aortic vascular smooth muscle cells; the actions are endothelia independent.
