Effect of prenatal restraint stress on the expressions of Bax, Bcl-2, Fas and FasL in hippocampus of the offspring
- VernacularTitle:产前束缚应激刺激对子代大鼠脑海马中Bax、Bcl-2、Fas和FasL表达的影响
- Author:
Zhengyu ZHANG
;
Simin MA
;
Jie WU
;
Tianbao SONG
- Publication Type:Journal Article
- Keywords:
prenatal stress;
hippocampus;
Bax;
Bcl-2;
Fas;
FasL
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of chronic restraint stress on the expressions of Bax, Bcl-2, Fas and FasL in hippocampus of the offsprings during the pregnancy. Methods Restraint stress was performed three times each day of pregnant women from day 13 to day 19 (each time for 45min). After delivery, the expression of Bax, Bcl-2, Fas and FasL in hippocampus of one-month-old female and male rats were respectively examined by immunohistochemical method. Results Compared with the control group, the expression level of Bax in stressed group is higher (P 0.05). Conclusion Restraint stress during the pregnancy can upgrade the expression of Bax and degrade the expression of Bcl-2 of the offsprings; no effect was found on the expressions of Fas and FasL of the offsprings.
