Genetic polymorphisms of interleukin-10 promoter region in patients with chronic HCV infection
- VernacularTitle:白细胞介素-10启动区基因多态性与慢性丙型肝炎的相关性
- Author:
Juntao ZENG
;
Zhengwen LIU
;
Qunying HAN
;
Ni ZHANG
- Publication Type:Journal Article
- Keywords:
IL-10;
gene polymorphism;
chronic hepatitis C
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between gene polymorphisms in IL-10 promoter region and the susceptibility and clinical phenotypes of HCV infection. Methods Two groups of subjects were studied. Group 1 included 85 treatment naive patients with chronic HCV infection, and group 2 included 75 healthy blood donors. Genotyping of IL-10 promoter-592 was performed by PCR-RFLP. Results No significant difference was found in IL-10 promoter-592 genotypes between the healthy individuals and HCV-infected patients. However, IL-10 promoter-592 genetype A/A appeared more frequently in patients with ALT≥80U/L than in those with ALT
