Expression of P53 and Sialyl Lewis-X in relation to invasion and metastasis of thyroid papillary carcinoma
- VernacularTitle:P53和Sialyl Lewis-X表达与甲状腺乳头状癌侵袭转移的关系
- Author:
Huaping GU
;
Debing LI
;
Zhengmeng ZHANG
;
Peizhong SHANG
- Publication Type:Journal Article
- Keywords:
thyroid neoplasm;
neoplasm;
gene expression regulation;
neoplasm metastasis;
immunohistochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of expression of P53 and SLeX with the potentials of invasion and metastasis in papillary thyroid carcinoma (PTC). Methods The expression of P53 and SLeX in 46 cases of PTC, 20 cases of nodular goiter(NG), 20 cases of chronic lymphocytic thyroiditis (CLT) and 15 cases of normal thyroid (NT) tissues was investigated by catalyzed signal amplification (CSA) immunohistochemical technique. Results The positive rate of P53 and SLeX in PTC was 65.2% (30/46) and 69.6% (32/46), respectively, which was higher than that in NG, CLT and NT (P
