Regulation of tazarotene on HB-EGF in hyperproliferative epidermis of psoriasis
- VernacularTitle:他扎罗汀对银屑病增殖表皮中肝素结合表皮生长因子样生长因子基因的调节作用
- Author:
Yan ZHENG
;
Shengshun TAN
;
Zhenhui PENG
;
Yanping XI
- Publication Type:Journal Article
- Keywords:
HB-EGF;
tazarotene;
psoriasis
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of tazarotene in active psoriasis vulgaris. Methods HB-EGF mRNA in active psoriatic lesions before and 10 days after the treatment with tazarotene was detected by hybridization in situ. Results There was nearly no expression of HB-EGF mRNA in psoriatic lesions (9.1%); after the treatment with tazarotene, there was expression of HB-EGF not only in basal layer (95.5%), but also focal expression in suprabasal layers of epidermis (77.3%). Conclusion Tazarotene can inhibit proliferation and induce apoptosis of keratinocytes though upregulating expression of HB-EGF in psoriatic epidermis.
