Study on the drug during coronary stent in animal
10.3760/cma.j.issn.1673-4181.2010.03.010
- VernacularTitle:药物洗脱冠状动脉支架系统动物实验研究
- Author:
Zhigang ZHANG
;
Wenyu WANG
;
Aiping SUN
- Publication Type:Journal Article
- Keywords:
Coronary stent;
Coronary angiography;
Biodegradable polymer-coating
- From:
International Journal of Biomedical Engineering
2010;33(3):172-175,后插2
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of clinical application of biodegradable polymer-coated drug-eluting stent. Methods Thirty each of the drug-eluting stent or bare-metal stents were implanted randomly into the anterior descending arteries, circumflex and right canine coronary arteries of thirty healthy pigs. The pathological examination was taken at 2 weeks to 6 months after coronary angiography to investigate the inflammation, thrombosis and endothelialization. Results Macroscopic observation of the stented arteries demonstrated complete incorporation of stent wires into the arterial wall and smooth vessel lumens. There were no significant differences existing between two kinds of the stents in terms of thrombosis, inflammation and endothelialization. The lumen loss in the biodegradable polymer-coated drug-eluting stent group is less than that in the bare-metal stent group. Conclusion The biodegradable polymer-coated drug-eluting stent is promising with good biocom-patibility, blood compatibility and phyaicochemical stability after being implanted into pig coronary arteries. The blood vessel transplanted with the drug-eluting stents maintains a high patency rate due to rapid endothelialization.
