Expression and significance of suppressor gene pten in human gastric cancer tissues
- VernacularTitle:PTEN抑癌基因在人胃癌组织中的表达及意义
- Author:
Xuewen GU
;
Yuexiang CHEN
;
Xiuchun TIAN
;
Fei CUI
;
Changren ZHU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms/pathology;
PTEN gene/biosynthesis;
Immunohistochemistry;
Prognosis
- From:
Cancer Research and Clinic
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of suppressor gene PTEN in gastric cancer tissues and its relationship with tumor biologic characteristics. Methods Using EnVision immunohistochemical methods, we examined the suppressor gene PTEN expression in 116 cases of gastric cancer, 35 cases dysplasia and 56 cases normal gastric mucosa specimens. Results The positive rate of PTEN (53.4 %, 62/116) was lower in gastric cancer tissue than in dysplasia (71.4 %, 25/35) and normal gastric mucosa specimens(100 %, 56/56) (P
