Clinical significance of serum vegf level alteration in patient with nasopharyngeal carcinoma
- VernacularTitle:鼻咽癌患者血清VEGF水平及临床意义
- Author:
Yan CHEN
;
Zhiping WU
;
Xiaoqun CHEN
;
Yulan GU
;
Congguo JIN
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
Serum vascular endothelial growth factor;
Clinical significance
- From:
Cancer Research and Clinic
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of serum vascular endothelial growth factor (VEGF) level in nasopharyngeal carcinoma patients. Methods Serum VEGF level of 55 nasopharyngeal carcinoma patients were measured by sandwich enzyme?- linked immunosorbent assay (ELISA). 40 normal healthy volunteers served as control. Results Serum VEGF level of nasopharyngeal carcinoma patients was significantly higher than that of control group (P =0.000); Serum VEGF level was significantly higher in advanced nasopharyngeal carcinoma stage (stage Ⅲ ~Ⅳ) than that in early stage(stageⅠ ~Ⅱ) (P =0.003); Serum VEGF level with nasopharyngeal carcinoma patients with lymphnode metastasis was significantly higher than that of patients without lymphnode metastasis. There was no significant relationship compared serum VEGF level in nasopharyngeal carcinoma patient's gender, age and pathological types. Conclusions Serum VEGF can be used as a marker of nasopharyngeal carcinoma for diagnosis and monitoring the progress and the prognosis of the disease.
