Significance and distribution of lymphopenia and anti-lymphocyte antibody in systemic lupus erythematosus

VernacularTitle:淋巴细胞减少及抗淋巴细胞抗体在系统性红斑狼疮中的分布及意义
Author: Chun LI ; Xiaoyan LU ; Jing LI ; Jing HE ; Hua YE ; Rong MU ; Zhanguo LI
Publication Type:Journal Article
Keywords: Lupus erythematosus,systemic; Lymphopenia; Antilymphocyte serum
From: Chinese Journal of Rheumatology 2009;13(5):316-319,前插2
CountryChina
Language:Chinese
Abstract: Objective To investigate the significance and distribution of lymphopenia and antilymphocyte antibody(ALA) in systemic lupus erythematosus (SLE) and to explore the role of ALA in lympho penia.Methods One hundred and ten in-patients who were admitted during February 2003 to February 2008 were retrospectively reviewed.Indirect immunofluorescence test was used to detect ALA.Results ① Lymphopenia (＜1.5×109/L) was observed in 68.2% patients.Lymphopenia was associated with skin rashes,serositis,renal involvement,NPSLE,leucopenia,ANA,ds-DNA antibody,ESR and IgG levels.The lymphocyte count and SLEDAI scores was more closely correlated than total white blood cell counts.②ALA was positive in 51/110 (46.4%) patients.ALA was associated with renal involvement,NPSLE,WBC count,C3 level decrease,ANA,dsDNA antibody and SLEDAI scores.Conclusion Lymphopenia is significantly associated with SLEDAI scores.ALA is possibly one cause of lymphcytopenia.In addition,ALA is also a parameter for disease activity,and is associated with organ involvement and outcomes.