Inhibitory effect of Chinese nutgall extracts on the secretion of IL-6 from mon ocytes induced by lipopolysaccharide of Porphyromonas gingivalis
- VernacularTitle:五倍子水提取物对PgLPS诱导单核细胞分泌IL-6的抑制作用
- Author:
Xiaohong YUE
;
Rongyin TANG
;
Zhiliang WANG
- Publication Type:Journal Article
- Keywords:
Nutgall extract;
Porphyromonas gingivalis;
Lipopolysacchari de;
Interleukin-6
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of Chinese nutgalls ex tr acts on the secretion of IL-6 from monocytes induced by lipopolysaccharide (LPS ) of Porphyromonas gingivalis (Pg). Methods:Monocytes ob tained by separating human blood cells were stimulated with LPS of Pg at 25 ?g/ml, radioimmunoassay (RIA) was used to examine the effect of Chinese nutgal ls extracts at the concentrations of 6.25-100 ?g/ml on the secretion of IL-6 in the supernatant of the cell culture. Results:Chinese nutgalls extracts at the concentrations(?g/ml) of 6.25,12.50, 25.00 ,50.00 and 100.00 inhibited IL-6 secretion from monocytes by(%) 34.6,46.4,48.5,52.7 and 54.9 res pectively.Conclusions:Extracts from Chinese nutgalls may inhibit the secretion of IL-6 from monocyte induced by LPS of Pg in a dose-depend ent manner.
