A Case of the Carrier of Reciprocal Translocation Which was Inherited from Patient with Recurrent Spontaneous Abortion.
- Author:
Yoon Sung NAM
1
;
Nam Keun KIM
;
Chang Jin JEONG
;
Sun Hee CHA
;
Kwang Yul CHA
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
- Publication Type:Case Report
- Keywords:
Recurrent spontaneous abortion;
Reciprocal translocation
- MeSH:
Abortion, Spontaneous*;
Child;
Family Characteristics;
Female;
Germ Cells;
Humans;
Incidence;
Infertility;
Karyotype;
Parents;
Patient Selection;
Pregnancy;
Translocation, Genetic
- From:Korean Journal of Obstetrics and Gynecology
2001;44(12):2348-2351
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A balanced translocation in a parent may produce unbalanced gametes leading to abortions or defective liveborn children, or interval infertility. It also may give rise to a balanced gamete resulting in a balanced carrier, or it may produce a cytogenetically normal gamete. The incidence of balanced chromosomal translocations in couples with multiple abortions was reported as 0% to 31%. This wide variation is related to the heterogeneous criteria used for patient selection. Because parents with balanced chromosomal rearrangements and history of only repeated abortions have a significant chance with each pregnancy of having a child with normal or balanced karyotype, the usual criteria for investigation include at least two abortions or reproductive losses. There is no evidence from several reported series that increasing the number of losses to three or more leads to any change in the yield of chromosomal rearrangements detected.
