Mechanism of aprotinin in auxiliary treatment of cerebral hemorrhage
- VernacularTitle:抑肽酶佐治脑出血脑水肿作用机制的探讨
- Author:
Chunkui ZHOU
;
Jiang WU
;
Lingqiu MENG
- Publication Type:Journal Article
- Keywords:
Aprotinin;
Cerebral hemorrhage;
Brain edema;
Kallikreins;
Thrombin;
Enzyme inhibitors
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the mechanism of aprotinin in auxiliary treatment of cerebral hemorrhage.Methods Totally 83 patients were divided into two groups: aprotinin treating group (42 cases) and control group (41 cases). The patients’ neurologic function was marked according to the European Standards of Grading For Cerebral Attacking. The volumes of edema were observed by CT in 10 days through 14 days after their attacks. The patients’ following prothrombin, activated partial thromboplastin time, and fibrinogen values were measured respectively before and after treatment.Results The therapeutic effects in aprotinin treating group(14.5?4.3, 19.0?5.2, 24.0?5.0, respectively) were significantly higher than those in control group(12.7?3.8, 16.8?4.8, 21.7?5.4, respectively).The producing of edema per day (0.212?0.064) in aprotinin treating group was significantly less than that in the control group(0.240?0.063). While the APTT after treatment was significantly longer ((1.2?1.8)s vs (0.4?1.8)s). Conclusions Aprotinin might inhibit the formation of cerebral edema and improve the neurologic function marks after attacks. It should be in treatment better to use aprotinin simultaneously than to use mannitol only. The mechanism properly shown is the preventive effects on bradykinin and thrombin.
