Hyperacute Radiation-Induced Injury of Liver in Rabbits: the Correlation Between SPIO-Enhanced MR Imaging and Irradiation Dose
- VernacularTitle:超急性期放射性肝损伤MRI菲立磁增强与照射剂量相关性研究
- Author:
Zhen JIANG
;
Junkang SHEN
;
Minghui QIAN
;
Caiyuan ZHANG
;
Zhian LU
- Publication Type:Journal Article
- Keywords:
MRI;
liver;
radiation injury;
superparamagnetic iron oxide
- From:
Journal of Practical Radiology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the correlation between the irradiation dose and superparamagnetic iron oxide (SPIO) enhanced MR imaging of the irradiated liver. Methods 25 rabbits were separated randomly into 5 groups. 3 days after focal irradiation (0, 10, 20, 30 and 40Gy), MR imaging was performed before and after SPIO injection with TSE-T 2W sequence, and the number of Kupffer cell containing SPIO particles was counted. The characteristics of MR enhancement were evaluated according to the pathological findings.Results The liver injury induced by no less than 30Gy irradiation can be detected by SPIO-enhanced T 2 weighted imaging (P
